The immunogen is a synthetic peptide directed towards the N terminal region of human ENG
Alternative Synonym:
END, HHT1, ORW1
Endoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex since it binds TGFB1 and TGFB3 with high affinity. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia.