CCND1 Antibody - N-terminal region
Artikelnummer:
ASB-ARP33370_P050
- Bilder (6)
| Artikelname: | CCND1 Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP33370_P050 |
| Hersteller Artikelnummer: | ARP33370_P050 |
| Alternativnummer: | ASB-ARP33370_P050-25UL,ASB-ARP33370_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | IHC, WB |
| Spezies Reaktivität: | Bovine, Canine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human CCND1 |
| Alternative Synonym: | BCL1, PRAD1, U21B31, D11S287E |
| CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
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Testis |
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WB Suggested Anti-CCND1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Human Liver |
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WB Suggested Anti-CCND1 antibody Titration: 1 ug/mL Sample Type: Human SH-SY5Y |
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Host: Rabbit Target Name: CCND1 Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1ug/ml |
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25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. |
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CCND1 antibody - N-terminal region (ARP33370_P050) in Human Liver using Western Blot |
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