TIMELESS Antibody - N-terminal region

Produktübersicht

• Artikelname: TIMELESS Antibody - N-terminal region
• Artikelnummer: ASB-ARP34186_P050
• Hersteller Artikelnummer: ARP34186_P050
• Alternativnummer: ASB-ARP34186_P050-25UL,ASB-ARP34186_P050-100UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: IHC, WB
• Spezies Reaktivität: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat, Sheep
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TIMELESS
• Alternative Synonym: TIM, TIM1, hTIM

Produktbeschreibung

The human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 0.5 mg/ml
• Molekulargewicht: 139 kDa
• NCBI: 8914
• UniProt: Q9UNS1
• Formulierung: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Bilder

Human kidney

WB Suggested Anti-TIMELESS Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Transfected 293T

25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. The protein may be modified by phosphorylation.

Host: Rabbit
Target Name: TIMELESS
Sample Tissue: Human THP-1 Whole Cell
Antibody Dilution: 1ug/ml

TIMELESS antibody - N-terminal region (ARP34186_P050) in Transfected 293T using Western Blot