NFKBIB Antibody - middle region
Artikelnummer:
ASB-ARP34381_P050
- Bilder (5)
| Artikelname: | NFKBIB Antibody - middle region |
| Artikelnummer: | ASB-ARP34381_P050 |
| Hersteller Artikelnummer: | ARP34381_P050 |
| Alternativnummer: | ASB-ARP34381_P050-25UL,ASB-ARP34381_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human NFKBIB |
| Alternative Synonym: | IKBB, TRIP9 |
| Inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta. Increased nuclear factor-kappaB (NF-kB) activity in the amnion during labor is associated with an increase in the expression of NF-kBp65 and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2. IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-766 BM449613.1 1-766 767-1189 BU634404.1 18-440 c 1190-1198 AI684894.1 1-9 c |
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Rabbit Anti-NFKBIB Antibody Catalog Number: ARP34381_P050 Formalin Fixed Paraffin Embedded Tissue: Human Testis Tissue Observed Staining: Nucleus, Cytoplasm Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec |
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WB Suggested Anti-NFKBIB Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: 721_B cell lysateNFKBIB is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells |
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Host: Rabbit Target Name: NFKBIB Sample Tissue: Mouse Testis Antibody Dilution: 1ug/ml |
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Host: Mouse Target Name: NFKBIB Sample Tissue: Mouse Testis Antibody Dilution: 1ug/ml |
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NFKBIB antibody - middle region (ARP34381_P050) in Human 721_B using Western Blot |
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