TRPM8 Antibody - N-terminal region

Produktübersicht

• Artikelname: TRPM8 Antibody - N-terminal region
• Artikelnummer: ASB-ARP35357_P050
• Hersteller Artikelnummer: ARP35357_P050
• Alternativnummer: ASB-ARP35357_P050-25UL,ASB-ARP35357_P050-100UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: IHC, WB
• Spezies Reaktivität: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TRPM8
• Alternative Synonym: TRPP8, LTRPC6, trp-p8, LTrpC-6

Produktbeschreibung

TRPM8 is the receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. TRPM8 is involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. TRPM8 was activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 0.5 mg/ml
• Molekulargewicht: 128 kDa
• NCBI: 79054
• UniProt: Q7Z2W7
• Formulierung: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Bilder

Immunohistochemistry with Prostate tissue at an antibody concentration of 5ug/ml using anti-TRPM8 antibody (ARP35357_P050)

WB Suggested Anti-TRPM8 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: ACHN cell lysate

25 ug of the indicated Human whole cell extracts was loaded onto a 6-18% SDS-PAGE gel. 0.5 ug/mL of the antibody was used in this experiment. An isoform containing the peptide sequence is present at ~ 19 kDa.

Host: Rabbit
Target Name: TRPM8
Sample Tissue: Human 293T Whole Cell
Antibody Dilution: 1ug/ml

TRPM8 antibody - N-terminal region (ARP35357_P050) in Human ACHN using Western Blot