KCNN2 Antibody - middle region

Produktübersicht

• Artikelname: KCNN2 Antibody - middle region
• Artikelnummer: ASB-ARP35439_P050
• Hersteller Artikelnummer: ARP35439_P050
• Alternativnummer: ASB-ARP35439_P050-25UL,ASB-ARP35439_P050-100UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: IHC, WB
• Spezies Reaktivität: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KCNN2
• Alternative Synonym: SK2, hSK2, SKCA2, KCa2.2, SKCa 2

Produktbeschreibung

KCNN2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This protein is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for KCNN2.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN2 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 0.5 mg/ml
• Molekulargewicht: 26kDa
• NCBI: 3781
• UniProt: Q6PJI0
• Formulierung: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Bilder

Sample Type:
Rhesus macaque spinal cordPrimary Antibody Dilution:
1:300Secondary Antibody:
Donkey anti Rabbit 488Secondary Antibody Dilution:
1:500Color/Signal Descriptions:
Green: KCNN2Gene Name:
KCNN2Submitted by:
Timur Mavlyutov, Ph. D., Department of Pharmacology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706

WB Suggested Anti-KCNN2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human Muscle

Host: Rabbit
Target Name: KCNN2
Sample Type: Human Fetal Heart
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: KCNN2
Sample Type: Human Fetal Lung
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: KCNN2
Sample Type: Human Fetal Muscle
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target: KCNN2
Positive control (+): Human liver (LI)
Negative control (-): HeLa (HL)
Antibody concentration: 1ug/ml

KCNN2 antibody - middle region (ARP35439_P050) in Human Muscle using Western Blot