CNOT8 Antibody - C-terminal region
Artikelnummer:
ASB-ARP35747_P050
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| Artikelname: | CNOT8 Antibody - C-terminal region |
| Artikelnummer: | ASB-ARP35747_P050 |
| Hersteller Artikelnummer: | ARP35747_P050 |
| Alternativnummer: | ASB-ARP35747_P050-25UL,ASB-ARP35747_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C-terminal region of Human CNOT8 |
| Alternative Synonym: | CAF1, POP2, CALIF, Caf1b, hCAF1 |
| CNOT8 has 3-5 poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. It associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. |
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