The immunogen is a synthetic peptide directed towards the C terminal region of mouse Tfam
Alternative Synonym:
Hmgt, mtTF, tsHM, Hmgts, mtTFA, tsHMG, AI661103
TFAM a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this protein is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns Sayre syndrome was produced when expression of the gene was eliminated by targeted disruption in heart and muscle cells.