SMAD1 Antibody - N-terminal region

Produktübersicht

• Artikelname: SMAD1 Antibody - N-terminal region
• Artikelnummer: ASB-ARP38692_T100
• Hersteller Artikelnummer: ARP38692_T100
• Alternativnummer: ASB-ARP38692_T100-25UL,ASB-ARP38692_T100-100UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: IHC, WB
• Spezies Reaktivität: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD1
• Alternative Synonym: BSP1, JV41, BSP-1, JV4-1, MADH1, MADR1

Produktbeschreibung

SMAD1 belongs to the SMAD family. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1 mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, SMAD1 can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of SMAD1 forms a complex with SMAD4, which is important for its function in the transcription regulation. SMAD1 is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1.0 mg/ml
• Molekulargewicht: 52kDa
• NCBI: 4086
• UniProt: Q99717
• Formulierung: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Bilder

Immunohistochemistry with Human Skin lysate tissue

SMAD1 antibody - N-terminal region (ARP38692_T100) validated by WB using Transfected 293T cell lysate at 2.5ug/ul.

Host: Rabbit
Target Name: SMAD9
Sample Tissue: Mouse Skeletal Muscle
Antibody Dilution: 1ug/ml

Host: Mouse
Target Name: SMAD9
Sample Tissue: Mouse Skeletal Muscle
Antibody Dilution: 1ug/ml

SMAD1 antibody - N-terminal region (ARP38692_T100) in Transfected 293T using Western Blot