PCBP1 Antibody - middle region
Artikelnummer:
ASB-ARP40631_P050
- Bilder (9)
| Artikelname: | PCBP1 Antibody - middle region |
| Artikelnummer: | ASB-ARP40631_P050 |
| Hersteller Artikelnummer: | ARP40631_P050 |
| Alternativnummer: | ASB-ARP40631_P050-25UL,ASB-ARP40631_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | IHC, WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of Human PCBP1 |
| Alternative Synonym: | HNRPX, HNRPE1, hnRNP-X, HEL-S-85, hnRNP-E1 |
| PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. |
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Rabbit Anti-PCBP1 Antibody Catalog Number: arp40631 Paraffin Embedded Tissue: Human Breast Antibody Concentration: 5 ug/ml |
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Anti-PCBP1 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. |
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Host: Rabbit Target Name: PCBP1 Sample Type: MCF7 Whole Cell lysates Antibody Dilution: 1.0ug/mlPCBP1 is supported by BioGPS gene expression data to be expressed in MCF7 |
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Host: Rabbit Target Name: PCBP1 Sample Tissue: Human HCT116 Antibody Dilution: 1.0ug/ml |
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Rabbit Anti-PCBP1 Antibody Catalog Number: arp40631 Paraffin Embedded Tissue: Human Breast Antibody Concentration: 5 ug/ml |
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Host: Mouse Target Name: PCBP1 Sample Tissue: Mouse Testis Antibody Dilution: 1ug/ml |
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25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. A second isoform of 33 kDa also contains the peptide, and the protein is phosphorylated. |
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Host: Rabbit Target Name: PCBP1 Sample Tissue: Human THP-1 Whole Cell Antibody Dilution: 1ug/ml |
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Western Blot |
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