SOCS1 Antibody - N-terminal region

Produktübersicht

• Artikelname: SOCS1 Antibody - N-terminal region
• Artikelnummer: ASB-ARP42147_T100
• Hersteller Artikelnummer: ARP42147_T100
• Alternativnummer: ASB-ARP42147_T100-25UL,ASB-ARP42147_T100-100UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: IHC, WB
• Spezies Reaktivität: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SOCS1
• Alternative Synonym: JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, TIP-3, SOCS-1

Produktbeschreibung

SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1.0 mg/ml
• Molekulargewicht: 23kDa
• NCBI: 8651
• UniProt: O15524
• Formulierung: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Bilder

Rabbit Anti-SOCS1 Antibody
Catalog Number: ARP42147
Paraffin Embedded Tissue: Human Kidney
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

SOCS1 antibody - N-terminal region (ARP42147_T100) validated by WB using Jurkat cell lysate at 0.2-1 ug/ml.

WB Suggested Anti-SOCS1 Antibody Titration: 1.25ug/ml
Sample Type: Jurkat Lysate (20ug)A,ASample Type: Jurkat cell lysate

SOCS1 antibody - N-terminal region (ARP42147_T100) validated by WB using Huh7 Cells transfected with microRNA at 1:1000.

Lanes:
1. Mouse WT brain extract (80ug) 2. Rat brain extract (80ug)
Primary Antibody Dilution:
2ug/ml
Secondary Antibody:
IRDye 800CW goat anti-rabbit from Li-COR Bioscience
Secondary Antibody Dilution:
1: 20,000
Gene Name:
SOCS1
Submitted by:
Dr. Yuzhi Chen, University of Arkansas for Medical Science

Host: Mouse
Target Name: SOCS1
Sample Tissue: Mouse Pancreas
Antibody Dilution: 1ug/ml

SOCS1 antibody - N-terminal region (ARP42147_T100) in Human Jurkat using Western Blot