Bovine, Canine, Guinea pig, Human, Mouse, Rabbit, Rat
Alternative Synonym:
I-, I-1, inhib, 0610038N18Rik
Ppp1r1a is an inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.