CEMIP2 Antibody - middle region

Produktübersicht

• Artikelname: CEMIP2 Antibody - middle region
• Artikelnummer: ASB-ARP42382_P050
• Hersteller Artikelnummer: ARP42382_P050
• Alternativnummer: ASB-ARP42382_P050-25UL,ASB-ARP42382_P050-100UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: WB
• Spezies Reaktivität: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TMEM2
• Alternative Synonym: TMEM2

Produktbeschreibung

This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 0.5 mg/ml
• Molekulargewicht: 154 kDa
• NCBI: 23670
• UniProt: Q9UHN6
• Formulierung: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Bilder

25 ug of the indicated Human whole cell extracts was loaded onto a 6-18% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. Isoforms present from ~41 kDa to ~24 kDa.

WB Suggested Anti-TMEM2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: PANC1 cell lysate

Host: Rabbit
Target Name: TMEM2
Sample Tissue: Human HCT15 Whole Cell
Antibody Dilution: 1ug/ml

25 ug of the indicated Human whole cell extracts was loaded onto a 6-18% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. In addition to the canonical isoform at 154 kDa, isoforms of ~131 kDa, 41 kDa, and 24 kDa also contain this peptide.

Western Blot