HSD11B1 Antibody - N-terminal region
Artikelnummer:
ASB-ARP45714_P050
- Bilder (8)
| Artikelname: | HSD11B1 Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP45714_P050 |
| Hersteller Artikelnummer: | ARP45714_P050 |
| Alternativnummer: | ASB-ARP45714_P050-25UL,ASB-ARP45714_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | IHC, WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human HSD11B1 |
| Alternative Synonym: | HDL, 11-DH, HSD11, HSD11B, HSD11L, CORTRD2, SDR26C1, 11-beta-HSD1 |
| HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene. |
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WB Suggested Anti-HSD11B1 Antibody Titration: 2 ug/ml Positive Control: Transient overexpression lysate of HSD11B1 and Non-overexpressed vector control lysate |
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Immunohistochemistry with Human Liver cell lysate tissue at an antibody concentration of 5.0ug/ml using anti-HSD11B1 antibody (ARP45714_P050) |
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WB Suggested Anti-HSD11B1 Antibody Titration: 1 ug/ml Positive Control: Fetal liver cell lysate |
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Host: Rat Target Name: HSD11B1 Sample Tissue: Rat Liver Antibody Dilution: 1ug/ml |
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Host: Rabbit Target: HSD11B1 Positive control (+): Human Placenta (PL) Negative control (-): Human cerebral cortex Antibody concentration: 1ug/ml |
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Host: Rabbit Target Name: HSD11B1 Sample Tissue: Rodent Rat Testis Antibody Dilution: 2ug/ml |
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Surface Plasmon Resonance Kinetic Characterization of Polyclonal Antibody Affinity. Purified polyclonal antibodies were immobilized on a Protein A/G coated Carterra LSA sensor chip (PAGH200M) at concentrations of 0.5, 5, and 50 ug/mL. Antibodies on the surface were exposed to interaction with peptides sequentially via microfluidic controlled flow at 333nM peptide concentration for kinetic characterization of the binders for affinity and specificity, followed by curve fitting using the Kinetics software. Kd determinations for either two or three concentrations were averaged and results and standard deviation are shown. |
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HSD11B1 antibody - N-terminal region (ARP45714_P050) in Human Fetal liver using Western Blot |
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