INHA Antibody - N-terminal region

Produktübersicht

• Artikelname: INHA Antibody - N-terminal region
• Artikelnummer: ASB-ARP53597_P050
• Hersteller Artikelnummer: ARP53597_P050
• Alternativnummer: ASB-ARP53597_P050-25UL,ASB-ARP53597_P050-100UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: WB
• Spezies Reaktivität: Bovine, Canine, Equine, Goat, Human, Mouse, Porcine, Rabbit, Rat, Sheep, Yeast
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human INHA

Produktbeschreibung

INHA joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 0.5 mg/ml
• Molekulargewicht: 40 kDa
• NCBI: 3623
• UniProt: P05111
• Formulierung: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Bilder

25 ug of the indicated Human whole cell or tissue extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment.

WB Suggested Anti-INHA Antibody Titration: 0.2-1 ug/ml
Positive Control: Human Liver

Host: Rabbit
Target: INHA
Positive control (+): MCF7 (N10)
Negative control (-): THP-1 (N30)
Antibody concentration: 1ug/ml

INHA antibody - N-terminal region (ARP53597_P050) in Human Liver using Western Blot