The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Host: Rabbit Target Name: MAPK1 Sample Type: Human Jurkat Antibody Dilution: 1.0ug/mlMAPK1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
Host: Rat Target Name: MAPK1 Sample Tissue: Rat Skeletal Muscle Antibody Dilution: 1ug/ml
25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 0.5 ug/mL of the antibody was used in this experiment.