MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. MCAM could be an adhesion molecule active in neural crest cells during embryonic development. MCAM acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
WB Suggested Anti-MCAM Antibody Titration: 1.0 ug/ml Positive Control: HepG2 Whole CellThere is BioGPS gene expression data showing that MCAM is expressed in HepG2
Host: Rabbit Target Name: MCAM Sample Type: Human Jurkat Antibody Dilution: 1.0ug/mlThere is BioGPS gene expression data showing that MCAM is expressed in Jurkat
Host: Rabbit Target Name: MCAM Sample Type: Human 721_B Antibody Dilution: 1.0ug/mlThere is BioGPS gene expression data showing that MCAM is expressed in 721_B
MCAM antibody - middle region (ARP63483_P050) in Human HepG2 using Western Blot
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