ACVR2B Antibody - C-terminal region, Rabbit, Polyclonal
Artikelnummer:
ASB-ARP75885_P050
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| Artikelname: | ACVR2B Antibody - C-terminal region, Rabbit, Polyclonal |
| Artikelnummer: | ASB-ARP75885_P050 |
| Hersteller Artikelnummer: | ARP75885_P050 |
| Alternativnummer: | ASB-ARP75885_P050-25UL,ASB-ARP75885_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Spezies Reaktivität: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C-terminal region of Human AVR2B |
| Alternative Synonym: | HTX4, ACTRIIB, ActR-IIB |
| Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. |
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