PSEN1 Antibody - middle region
Artikelnummer:
ASB-ARP96893_P050
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| Artikelname: | PSEN1 Antibody - middle region |
| Artikelnummer: | ASB-ARP96893_P050 |
| Hersteller Artikelnummer: | ARP96893_P050 |
| Alternativnummer: | ASB-ARP96893_P050-25UL,ASB-ARP96893_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle terminal region of human PSEN1 |
| Alternative Synonym: | AD3, FAD, PS1, PS-1, S182, ACNINV3 |
| Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. |
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