DAB2 Antibody - C-terminal region
Artikelnummer:
ASB-ARP97516_P050
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| Artikelname: | DAB2 Antibody - C-terminal region |
| Artikelnummer: | ASB-ARP97516_P050 |
| Hersteller Artikelnummer: | ARP97516_P050 |
| Alternativnummer: | ASB-ARP97516_P050-25UL,ASB-ARP97516_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human DAB2 |
| Alternative Synonym: | DOC2, DOC-2 |
| This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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