RAD17 Antibody - C-terminal region
Artikelnummer:
ASB-ARP97951_P050
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| Artikelname: | RAD17 Antibody - C-terminal region |
| Artikelnummer: | ASB-ARP97951_P050 |
| Hersteller Artikelnummer: | ARP97951_P050 |
| Alternativnummer: | ASB-ARP97951_P050-25UL,ASB-ARP97951_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human RAD17 |
| Alternative Synonym: | CCYC, R24L, RAD24, HRAD17, RAD17SP |
| The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. |
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