The immunogen is a synthetic peptide directed towards the N terminal region of human BCL2L1
Alternative Synonym:
BCLX, BCL2L, Bcl-X, PPP1R52, BCL-XL/S
BCL2L1 encodes a protein which belongs to the BCL-2 protein family. The proteins encoded by BCL2L1 are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis.