DDR1 Antibody
Artikelnummer:
ASB-OAAB04736
- Bilder (0)
| Artikelname: | DDR1 Antibody |
| Artikelnummer: | ASB-OAAB04736 |
| Hersteller Artikelnummer: | OAAB04736 |
| Alternativnummer: | ASB-OAAB04736-400UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | IHC-P, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | This MCK10 antibody is generated from rabbits immunized with recombinant human MCK10 protein. |
| Alternative Synonym: | CAK, DDR, NEP, HGK2, PTK3, RTK6, TRKE, CD167, EDDR1, MCK10, NTRK4, PTK3A |
| Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. |
Produktgarantie und fachkundiger Support
