FBXW7 Antibody - N-terminal region

Produktübersicht

• Artikelname: FBXW7 Antibody - N-terminal region
• Artikelnummer: ASB-OAAB19237
• Hersteller Artikelnummer: OAAB19237
• Alternativnummer: ASB-OAAB19237-400UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: WB
• Spezies Reaktivität: Human
• Immunogen: This FBXW7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 177-208 amino acids from the N-terminal region of human FBXW7.
• Alternative Synonym: AGO, CDC4, FBW6, FBW7, hAgo, FBX30, FBXW6, SEL10, hCdc4, FBXO30, SEL-10

Produktbeschreibung

Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.

Produkteigenschaften

• Klonalität: Polyclonal
• Molekulargewicht: 80 kDa
• NCBI: 55294
• UniProt: Q969H0
• Formulierung: Liquid. PBS with 0.09% (W/V) sodium azide.