MLF1 Antibody - C-terminal region
Artikelnummer:
ASB-OAAB19269
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| Artikelname: | MLF1 Antibody - C-terminal region |
| Artikelnummer: | ASB-OAAB19269 |
| Hersteller Artikelnummer: | OAAB19269 |
| Alternativnummer: | ASB-OAAB19269-400UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Human |
| Immunogen: | This MLF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 232-266 amino acids from the C-terminal region of human MLF1. |
| Alternative Synonym: | Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1 |
| Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. |
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