CK17 Antibody, IgG2b, Clone: [3B12], Mouse, Monoclonal
Artikelnummer:
ASB-OAAD00314
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| Artikelname: | CK17 Antibody, IgG2b, Clone: [3B12], Mouse, Monoclonal |
| Artikelnummer: | ASB-OAAD00314 |
| Hersteller Artikelnummer: | OAAD00314 |
| Alternativnummer: | ASB-OAAD00314-0.1ML |
| Hersteller: | Aviva |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | IHC, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Purified recombinant fragment of CK17 expressed in E. Coli. |
| Alternative Synonym: | PC, K17, PC2, 39.1, CK-17, PCHC1 |
| CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. |
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