TUBB3 Antibody, IgG1, Clone: [2000000000], Mouse, Monoclonal
Artikelnummer:
ASB-OAAD00318
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| Artikelname: | TUBB3 Antibody, IgG1, Clone: [2000000000], Mouse, Monoclonal |
| Artikelnummer: | ASB-OAAD00318 |
| Hersteller Artikelnummer: | OAAD00318 |
| Alternativnummer: | ASB-OAAD00318-0.1ML |
| Hersteller: | Aviva |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, IF, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Purified recombinant fragment of human TUBB3 expressed in E. Coli. |
| Alternative Synonym: | CDCBM, FEOM3, TUBB4, CDCBM1, CFEOM3, beta-4, CFEOM3A |
| Tubulin, beta 3, also known as TUBB3. Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non exchangeable site on the alpha-chain. Tubulin is a highly conserved protein with a molecular weight of - 50 kD. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. The two main tubulin isoforms, AA-and AA,-tubulin, are usually products of separate genes. The AA,-tubulin family includes six expressed genes that produce the polypeptide isoforms known as Classes I through VI, each of which have a distinct pattern of expression. Class III AA,-tubulin is found in neurons and mammalian testis cells and is widely used as a neuronal marker in developmental neurobiology, neoplasia, and stem cell research. Class III AA,-tubulin expression in neuronal and neuroblastic tumors is differentiation dependent, and its expression in certain non-neuronal neoplasms has been associated with poor prognosis and/or resistance to chemotherapy. |
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