KDR Antibody, IgG1, Clone: [4B4], Mouse, Monoclonal
Artikelnummer:
ASB-OAAD00326
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| Artikelname: | KDR Antibody, IgG1, Clone: [4B4], Mouse, Monoclonal |
| Artikelnummer: | ASB-OAAD00326 |
| Hersteller Artikelnummer: | OAAD00326 |
| Alternativnummer: | ASB-OAAD00326-0.1ML |
| Hersteller: | Aviva |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, IF, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells. |
| Alternative Synonym: | FLK1, CD309, VEGFR, VEGFR2 |
| KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. |
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