FLT4 Antibody, IgG1, Clone: [4H4], Mouse, Monoclonal
Artikelnummer:
ASB-OAAD00365
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| Artikelname: | FLT4 Antibody, IgG1, Clone: [4H4], Mouse, Monoclonal |
| Artikelnummer: | ASB-OAAD00365 |
| Hersteller Artikelnummer: | OAAD00365 |
| Alternativnummer: | ASB-OAAD00365-0.1ML |
| Hersteller: | Aviva |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Purified recombinant fragment of human FLT4 expressed in E. Coli. |
| Alternative Synonym: | PCL, CHTD7, FLT-4, FLT41, LMPH1A, LMPHM1, VEGFR3, VEGFR-3 |
| This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. Tissue specificity: Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain. VEGFR-3 is induced in all endothelial cells (ECAAs) during early embryogenesis, and its expression eventually disappears from the vascular endothelial cells of adult tissues. VEGFR-3 is constitutively expressed in the adult lymphatic endothelium. Although VEGFR-3 is not expressed in adult blood vessels, it is induced in vascular endothelial cells of tumor-bearing tissues.VEGFR-3 expression in adults is largely restricted to the endothelial cells of the lymphatic system, and high endothelial venules (HEV). |
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