TAB2 Antibody, IgG1, Clone: [3B5], Mouse, Monoclonal
Artikelnummer:
ASB-OAAD00384
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| Artikelname: | TAB2 Antibody, IgG1, Clone: [3B5], Mouse, Monoclonal |
| Artikelnummer: | ASB-OAAD00384 |
| Hersteller Artikelnummer: | OAAD00384 |
| Alternativnummer: | ASB-OAAD00384-0.1ML |
| Hersteller: | Aviva |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Purified recombinant fragment of human TAB2 expressed in E. Coli. |
| Alternative Synonym: | CHTD2, TAB-2, MAP3K7IP2 |
| The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. |
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