ELK1 Antibody, IgG1, Clone: [7E10D5 7E10E8], Mouse, Monoclonal
Artikelnummer:
ASB-OAAD00439
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| Artikelname: | ELK1 Antibody, IgG1, Clone: [7E10D5 7E10E8], Mouse, Monoclonal |
| Artikelnummer: | ASB-OAAD00439 |
| Hersteller Artikelnummer: | OAAD00439 |
| Alternativnummer: | ASB-OAAD00439-0.1MG |
| Hersteller: | Aviva |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | BEC2, ELK1, Kv12.3 |
| The transcription factor ELK1 is a family of member of ETS oncogene family and of the ternary complex factor (TCF) subfamily, which is located on chromosome Xp11.2 and stimulates transcription. binds to purine-rich DNA sequences. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus, It appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1phosphorylation and activa- tion correlate with MAP kinase activity, and interfering mutants of MAP kinase block Elk1 activation in vivo. More recent studies have shown that Elk1 is also a target of the Stress Activated Kinase SAPK/JNK. Phosphorylation of Elk1 has also been implicated in synaptic plasticity in the adult hippocampus. |
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