The antiserum was produced against synthesized peptide derived from human STEA3.
Alternative Synonym:
AHMIO2,dudlin-2,dudulin-2,metalloreductase STEAP3,pHyde,six-transmembrane epithelial antigen of prostate 3,STEAP family member 3, metalloreductase,STMP3,TSAP6,tumor suppressor pHyde,tumor suppressor-activated pathway protein 6.
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
