p53 Antibody (Acetyl-Lys379)
Artikelnummer:
ASB-OAAF08186
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| Artikelname: | p53 Antibody (Acetyl-Lys379) |
| Artikelnummer: | ASB-OAAF08186 |
| Hersteller Artikelnummer: | OAAF08186 |
| Alternativnummer: | ASB-OAAF08186-100UG |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | ELISA, ICC, IF, IHC-P, WB |
| Spezies Reaktivität: | Human, Mouse, Rat |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human p53 around the acetylated site of Lys379. |
| Alternative Synonym: | antigen NY-CO-13,BCC7,BMFS5,cellular tumor antigen p53,LFS1,mutant tumor protein 53,P53,p53 tumor suppressor,phosphoprotein p53,transformation-related protein 53,TRP53,tumor protein 53,Tumor suppressor p53,tumor supressor p53. |
| Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). |
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