MBP Antibody, Clone: [ABT-MBP], Mouse, Monoclonal
Artikelnummer:
ASB-OAAF08324
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| Artikelname: | MBP Antibody, Clone: [ABT-MBP], Mouse, Monoclonal |
| Artikelnummer: | ASB-OAAF08324 |
| Hersteller Artikelnummer: | OAAF08324 |
| Alternativnummer: | ASB-OAAF08324-0.1ML,ASB-OAAF08324-0.05ML |
| Hersteller: | Aviva |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | IHC |
| Spezies Reaktivität: | Human |
| Immunogen: | Synthetic peptide |
| Alternative Synonym: | Golli-MBP,myelin A1 protein,myelin basic protein,myelin membrane encephalitogenic protein,proline-rich proteoglycan 2. |
| The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. |
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