VHL Antibody, Clone: [ABT-PVHL], Mouse, Monoclonal
Artikelnummer:
ASB-OAAF08344
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| Artikelname: | VHL Antibody, Clone: [ABT-PVHL], Mouse, Monoclonal |
| Artikelnummer: | ASB-OAAF08344 |
| Hersteller Artikelnummer: | OAAF08344 |
| Alternativnummer: | ASB-OAAF08344-100UL,ASB-OAAF08344-50UL |
| Hersteller: | Aviva |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | IHC-P |
| Immunogen: | The antiserum was produced against synthesized peptide derived between 170-213 aa of human VHL. The exact sequence is proprietary. |
| Alternative Synonym: | RCA1, VHL1, pVHL, HRCA1 |
| Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
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