WT1 Antibody, Clone: [ABT-WT1], Mouse, Monoclonal

Produktübersicht

• Artikelname: WT1 Antibody, Clone: [ABT-WT1], Mouse, Monoclonal
• Artikelnummer: ASB-OAAF08361
• Hersteller Artikelnummer: OAAF08361
• Alternativnummer: ASB-OAAF08361-0.1ML,ASB-OAAF08361-0.05ML
• Hersteller: Aviva
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Synthetic peptide
• Alternative Synonym: AWT1,GUD,NPHS4,WAGR,Wilms tumor 1,Wilms tumor protein,WIT-2,WT33.

Produktbeschreibung

Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5-GCG(T/G)GGGCG-3 (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [ABT-WT1]
• Molekulargewicht: 55 kDa
• NCBI: 7490
• UniProt: P19544
• Formulierung: PBS, pH7.2, 0.03% Proclin 300, 50% glycerol