Anti-ERAB Polyclonal Antibody, Rabbit
Artikelnummer:
ASB-OAAI00011
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| Artikelname: | Anti-ERAB Polyclonal Antibody, Rabbit |
| Artikelnummer: | ASB-OAAI00011 |
| Hersteller Artikelnummer: | OAAI00011 |
| Alternativnummer: | ASB-OAAI00011-100UG |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | FC, IHC, IP, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | A synthetic peptide corresponding to aa 100-116 of human ERAB protein. |
| Alternative Synonym: | 17b-HSD10,3-hydroxy-2-methylbutyryl-CoA dehydrogenase,3-hydroxyacyl-CoA dehydrogenase type-2,ABAD,AB-binding alcohol dehydrogenase,amyloid-beta peptide binding alcohol dehydrogenase,CAMR,DUPXp11.22,endoplasmic reticulum-associated amyloid beta-peptide-binding protein,ERAB,HADH2,HCD2,HSD10MD,MHBD,mitochondrial ribonuclease P protein 2,mitochondrial RNase P subunit 2,MRPP2,MRX17,MRX31,MRXS10,SCHAD,SDR5C1,short chain L-3-hydroxyacyl-CoA dehydrogenase type 2,short chain type dehydrogenase/reductase XH98G2. |
| Mutations in several genes associated with early onset Alzheimers result in increased extracellular concentRations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. It is this longer form of Ab that has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II has been identified. It is shown to be expressed at high levels in Alzheimers disease-affected brain. ERAB may contribute to neuronal dysfunction in Alzheimers disease. |
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