Anti-Sentrin-2/SUMO-2 Polyclonal Antibody, Rabbit
Artikelnummer:
ASB-OAAI00015
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| Artikelname: | Anti-Sentrin-2/SUMO-2 Polyclonal Antibody, Rabbit |
| Artikelnummer: | ASB-OAAI00015 |
| Hersteller Artikelnummer: | OAAI00015 |
| Alternativnummer: | ASB-OAAI00015-100UG |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, FC, IHC, IP, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | A synthetic peptide derived from C-terminus of human Sentrin-2 protein. This sequence is identical to human, mouse and rat. |
| Alternative Synonym: | HSMT3,sentrin 2,small ubiquitin-related modifier 2,SMT3 homolog 2,SMT3 suppressor of mif two 3 homolog 2,Smt3A,SMT3B,SMT3H2,SUMO3,ubiquitin-like protein SMT3A,ubiquitin-like protein SMT3B. |
| Sentrin-2 also known as SUMO-2 is a 95-amino acids peptide that has high homologous to Sentrin-1/SUMO-1. This novel ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substRates requires prior activation by the E1 complex SAE1-SAE2 and linage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. |
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