Anti-C-Jun Antibody (Phospho-Thr239), Rabbit, Polyclonal
Artikelnummer:
ASB-OAAI00055
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| Artikelname: | Anti-C-Jun Antibody (Phospho-Thr239), Rabbit, Polyclonal |
| Artikelnummer: | ASB-OAAI00055 |
| Hersteller Artikelnummer: | OAAI00055 |
| Alternativnummer: | ASB-OAAI00055-100UG |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, FC, IHC, IP, WB |
| Spezies Reaktivität: | Human, Mouse |
| Immunogen: | A synthetic peptide corresponding to the epitope -GETPP-at a phosphorylation site Thr 239 of human c-Jun protein. This sequence is identical within human, rat, mouse, bovine and dog. |
| Alternative Synonym: | activator protein 1,AP1,AP-1,c-Jun,cJUN,enhancer-binding protein AP1,Jun activation domain binding protein,jun oncogene,p39,proto-oncogene cJun,proto-oncogene c-Jun,transcription factor AP-1,v-jun avian sarcoma virus 17 oncogene homolog,v-jun sarcoma virus 17 oncogene homolog. |
| c-Jun, also known as AP1, v-Jun or AH119, is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 as well as Thr 91 and Thr93. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun-dependent transcription. The MAP kinase homologue SAPK/JNK binds to the amino-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73 and Thr91/93. The phosphorylation of Thr239 is catalysed by The inhibition of GSK3 is not required for the dephosphorylation of Thr239 in response to LPS, and nor is the phosphorylation of Thr91 and Thr93 required for the TPA- or EGF-induced dephosphorylation of Thr239 in fibroblasts. The agonist-induced dephosphorylation of Thr239 may involve a conformational change that exposes Thr239 to dephosphorylation and/or the activation of a Thr239 phosphatase. |
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