Anti-NF-kB p105/p50 Antibody (Phospho-S337), Rabbit, Polyclonal
Artikelnummer:
ASB-OAAI00072
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| Artikelname: | Anti-NF-kB p105/p50 Antibody (Phospho-S337), Rabbit, Polyclonal |
| Artikelnummer: | ASB-OAAI00072 |
| Hersteller Artikelnummer: | OAAI00072 |
| Alternativnummer: | ASB-OAAI00072-100UG |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, FC, IHC, IP, WB |
| Spezies Reaktivität: | Human, Mouse |
| Immunogen: | A synthetic peptide corresponding to the epitope containing a phosphorylation site 337 human NFkB/p105 protein. This sequence is identical within human and mouse. |
| Alternative Synonym: | CVID12,DNA-binding factor KBF1,EBP-1,KBF1,NFkappaB,NF-kappaB,NF-kappa-B1,NF-kappabeta,NF-kB,NF-kB1,NFKB-p105,NFKB-p50,nuclear factor kappa-B DNA binding subunit,nuclear factor NF-kappa-B p105 subunit,nuclear factor NF-kappa-B p50 subunit,nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. |
| NfkB is a heterodimer that consists of a 50 kDA DNA binding subunit (p50/NFkB1) and a 65 kDa transactivation subnit (p65/ReIA). Both of these subunits exhibit sequence homology to the proto-oncogene c-Rel. The NF-kB1 gene encodes a 105 kDa protein which can undergo cotranslational processing by teh 26S proteasome to produce a 50 kDa protein. The 105 kDa protein is a Rel protein-specific transcription inhibitor and the 50 kDa protein a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. |
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