A synthetic peptide surrounding to the epitope -LDSRL-S-PPAGLF-with phosphorylation sites at Serine 780 of STAT5a protein from human, mouse, rat, chicken dog and bovine origins.
Alternative Synonym:
epididymis secretory sperm binding protein,MGF,signal transducer and activator of transcription 5A,STAT5.
STAT proteins (Signal transducer and activator of transcription) belong to a family of cytoplasmic transcription factors that can be phosphorylated by a lignad binding to its cell surface receptor. Activation of STAT5a induces dimerization, nuclear translocation and DNA binding. Stat5A is activated by IL-2, IL-7, IL-15, IL-3, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin, activation and dimerization of Stat5A requires phosphorylation of STATs.