Anti-E2F2 Polyclonal Antibody, Rabbit
Artikelnummer:
ASB-OAAI00116
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| Artikelname: | Anti-E2F2 Polyclonal Antibody, Rabbit |
| Artikelnummer: | ASB-OAAI00116 |
| Hersteller Artikelnummer: | OAAI00116 |
| Alternativnummer: | ASB-OAAI00116-100UG |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, FC, IHC, IP, WB |
| Spezies Reaktivität: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide corresponding to N-terminal of human E2F2. |
| Alternative Synonym: | E2F-2,transcription factor E2F2. |
| E2F2 belongs to E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins, and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. |
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