Anti-Estrogen Receptor 1 Polyclonal Antibody, Rabbit
Artikelnummer:
ASB-OAAI00127
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| Artikelname: | Anti-Estrogen Receptor 1 Polyclonal Antibody, Rabbit |
| Artikelnummer: | ASB-OAAI00127 |
| Hersteller Artikelnummer: | OAAI00127 |
| Alternativnummer: | ASB-OAAI00127-100UG |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, FC, IHC, IP, WB |
| Spezies Reaktivität: | Human, Mouse, Rat |
| Immunogen: | A synthetic peptide corresponding to the C-terminus of human estrogen receptor protein. This sequence is identical to human, Gorilla, Bovine, etc. |
| Alternative Synonym: | E2 receptor alpha,ER,Era,ER-alpha,ESR,ESRA,estradiol receptor,estrogen nuclear receptor alpha,estrogen receptor,estrogen receptor alpha E1-E2-1-2,estrogen receptor alpha E1-N2-E2-1-2,ESTRR,NR3A1,nuclear receptor subfamily 3 group A member 1,oestrogen receptor alpha. |
| ER (estrogen receptor) belongs to a member of the steroid receptor superfamily, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding and activation of transcription. This protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. ER regulates transcription by its phosphorylation at multiple sites, such as serine 104, 106, 118, 167 and 305. Phosphorylation of certain serine at ER may relate to breast cancer process and on-going treatment. |
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