A synthetic peptide corresponding to the internal portion of Osteopontin protein sequence. This sequence is identical to human, rat and mouse origins.
Alternative Synonym:
BNSP,BSPI,early T-lymphocyte activation 1,ETA-1,nephropontin,OPN,osteopontin,osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein,secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1),secreted phosphoprotein 1 variant 6,SPP1/CALPHA1 fusion,urinary stone protein,uropontin.
Osteopontin (OPN or Early T-Lymphocyte Activation-1: Eta-1), also referred to as transformation-associated secreted phosphoprotein, bone sialoprotein I, and minopotin, is a highly phosphorylated and glycosylated phosphoprtein that is expressed in many tissues. It is acidic, calcium-binding, cell surface-binding sequences (RGD)-containing protein was originally isolated from bone matrix. Osteopontin has been found in kidney, placenta, blood vessels. It is over-expressed in a variety of cancers, including lung, breast, colorectal, stomach, ovarian, melanoma and mesothelioma.