A synthetic peptide corresponding to C-term of ubiquitin protein.
Alternative Synonym:
epididymis secretory protein Li 50,HEL-S-50,polyubiquitin B,polyubiquitin-B.
Ubiquitin (Ub) is a highly conserved protein of approximately 8.5 kDa. It plays a very important role in regulated non-ysosomal ATP dependent protein degradation. The protein to be degraded is covalently attached to C-term of ubiquitin, and the ubiquinated protein is then selectively degraded by a 26S complex, multicatalytic cytosolic and nuclear protease termed proteasome. The Ub-proteasome proteolytic pathway, which is a complex process, is implicated to be of great importance for regulating numerous cellular processes.