Anti-CD40 Antibody, Rabbit, Polyclonal
Artikelnummer:
ASB-OAAI00212
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| Artikelname: | Anti-CD40 Antibody, Rabbit, Polyclonal |
| Artikelnummer: | ASB-OAAI00212 |
| Hersteller Artikelnummer: | OAAI00212 |
| Alternativnummer: | ASB-OAAI00212-100UG |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, FC, IHC, IP, WB |
| Spezies Reaktivität: | Human, Mouse, Rat |
| Immunogen: | A Synthetic peptide QPVTQEDGKESRISVQERQ derived from human CD40 (258-277aa) was used as an immunogen. |
| Alternative Synonym: | B cell surface antigen CD40,B cell-associated molecule,Bp50,CD40 molecule, TNF receptor superfamily member 5,CD40L receptor,CDW40,p50,TNFRSF5,tumor necrosis factor receptor superfamily member 5. |
| The CD40 is a member of the TNF-receptor superfamily. It is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T-cell dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). CD40 is a B cell surface antigen. |
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