This antibody was selected against a fusion protein consisting of EGF domains 1-12 of murine Notch1 fused to a human Fc domain and binds to to the NRR of mouse Notch1.
Alternative Synonym:
AOS5,AOVD1,hN1,neurogenic locus notch homolog protein 1,notch 1,Notch homolog 1, translocation-associated,TAN1,translocation-associated notch protein TAN-1.
This is a chimeric antibody created for improved compatibility with existing reagents, assays and techniques.
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH
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