A54 human anti-CD40 scFv was selected from the n-CoDeR phage display library after 4 rounds of selections using biotinylated CD40-FcGamma fusion protein as bait and subsequent capture of bound phages on streptavidin-caoted magnetic beads.
Alternative Synonym:
B cell surface antigen CD40,B cell-associated molecule,B-cell surface antigen CD40,Bp50,CD40 molecule, TNF receptor superfamily member 5,CD40L receptor,CDW40,p50,TNFRSF5,tumor necrosis factor receptor superfamily member 5.
This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
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