Bovine, Canine, Equine, Human, Mouse, Porcine, Rat
Immunogen:
KLH conjugated synthetic peptide derived from human MDC1
Konjugation:
Unconjugated
Alternative Synonym:
homologue to Drosophila photoreceptor protein calphotin,mediator of DNA damage checkpoint protein 1,NFBD1,nuclear factor with BRCT domains 1.
Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by Ser-139 phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
