Bovine, Canine, Chinese Hamster, Gallus, Goat, Human, Mouse, Porcine, Rat, Sheep
Immunogen:
Range: Tyr631 - Trp885
Alternative Synonym:
hVps34,phosphatidylinositol 3-kinase catalytic subunit type 3,phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,phosphoinositide-3-kinase, class 3,PI3K type 3,PI3-kinase type 3,PtdIns-3-kinase type 3,VPS34.
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate, different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
